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Fig. 3. Histological assessment of brain damage in the Zucker diabetic fatty (ZDF) and Zucker diabetic lean (ZDL) rat model. (A) H&E staining of brain tissue sections of lean (ZDL) and obese (ZDF) rats shows cell morphologic changes in the penumbra after focal cerebral ischemia and remote ischemic postconditioning (RIPostC) treatment. The areas within the squares are shown at higher magnification (× 20) to illustrate the pattern of cell destruction in the cortex and striatum of the penumbra of brain sections (scale bar= 100 μm). Quantification of the infarct volume (B) and quantitative analysis of the number of pyknotic cells per mm2 in the striatum (C) and cortex (D) of the penumbra after ischemia and RIPostC. Values are presented as mean± standard deviation. *P<0.05, P<0.01 RIPostC vs. ischemia group; P<0.001, §P<0.0001 lean vs. obese group.
J Obes Metab Syndr 2024;33:76~87 https://doi.org/10.7570/jomes23038