Fig. 4. Effects of treatment with ALA on (A) plasma levels of irisin and protein expression and quantification of (B) phosphorylated AMP-activated protein kinase (p-AMPK), (C) phosphorylated acetyl-CoA carboxylase (p-ACC), and (D) liver kinase B1 (LKB1) in inguinal white adipose tissue of ovariectomized rats. Data are expressed as mean±standard error of the mean. *P<0.05 vs. Sham; †P<0.05 vs. ovariectomy (Ovx) (n=6–11). ALA2, alpha-lipoic acid treatment (200 mg/kg/day, gavage); ALA3, alpha-lipoic acid (300 mg/kg/day, gavage) for 8 weeks.
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