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Fig. 4. Obesogenic memory in a subgroup of patients from the Leipzig Obesity Biobank with obesity and type 2 diabetes mellitus (T2DM) undergoing bariatric surgery (n=100). In the context of a two-step bariatric surgery procedure with an initial sleeve gastrectomy (baseline) and a Roux-en-Y gastric bypass surgery (up to 24 months), we investigated adipose tissue (AT) histology and gene expression signatures as described in Schmitz et al.94 We found two distinct directions of responses to weight loss characterized by remission (n=68) or reoccurrence (n=32) of T2DM 2 years after the initial surgery. Mechanisms for sustained or delayed obesogenic memory specifically in AT remain unclear. Average age, body mass index (BMI), and glycosylated hemoglobin (HbA1c) are shown at baseline and at approximately 2 years after significant average weight loss. AT signatures but not BMI or age was associated with T2DM remission. The figure displays data included into a previous original publication by the author’s research group.94
J Obes Metab Syndr 2024;33:275~288 https://doi.org/10.7570/jomes24013
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