Fig. 3. Quercetin suppresses expression of inflammatory receptors/ligands and their signaling pathway. Expression of (A) TLR2/TLR4, and (B) TNFRSF9/TNFSF9 (4-1BB/4-1BBL) gene in adipose tissue from mice fed either a regular diet (RD), a high-fat diet (HFD) or a high-fat diet containing 0.05% quercetin (HFD+Que) for 9 weeks. The intensity of the bands was densitometrically measured and normalized to the mRNA levels of 36B4 gene. Results are means±SEM. *P<0.05, †P<0.01, ‡P<0.001 compared with obese mice fed on HFD. Expression of (C) phosphorylated-JNK and JNK (D) IκB-α protein in adipose tissue from mice fed either a regular diet (RD), a high-fat diet (HFD) or a high-fat diet containing 0.05% quercetin (HFD+Que) for 9 weeks. The amount of phosphorylated-JNK, JNK and IκB-α was assessed by western blotting with appropriate antibodies.
Korean J Obes 2014;23:170~178
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