pISSN 2508-6235 eISSN 2508-7576

Table. 1.

Large clinical studies about the relationship of BMI with mortality

AuthorStudy typePopulationStudy sizeEnd pointFollow-up durationMajor findings
Flegal et al. (2013)8Meta-analysisGeneral population28,800,000All-cause mortality1-42 yearsOW (25≤BMI<30) vs NW (18.5≤BMI<25) subjects (HR 0.94; 95% CI, 0.91-0.96)OB (30≤BMI) vs NW subjects (HR 1.18; 95% CI, 1.12-1.25)
The Global BMI Mortality Collaboration (2016)9Meta-analysisGeneral population10,625,411All-cause mortality13.7 yearsUW grade1 (18.5≤BMI<20) vs NW subjects (HR 1.13; 95% CI, 1.09-1.17)OW grade 1 (25≤BMI<27.5) vs NW subjects (HR 1.07; 95% CI, 1.07-1.08)OW grade 2 (27.5≤BMI<30) vs NW subjects (HR 1.20; 95% CI, 1.18-1.22)OB grade 1 (30≤BMI<35) vs NW subjects (HR 1.45; 95% CI, 1.41-1.48)OB grade 2 (35≤BMI<40) vs NW subjects (HR 1.94; 95% CI, 1.87-2.01)
Aune et al. (2016)10Meta-analysisGeneral population30,233,329All-cause mortality13.8 yearsNever smoker: lowest mortality at BMI 23-24Healthy never smoker: lowest mortality at BMI 22-23Never smoker with ≥20 years follow up: lowest mortality at BMI 20-22
Zaccardi et al. (2017)12Meta-analysisType 2 Diabetes414,587All-cause mortality2.7-15.9 yearsLowest mortality at BMI 31-35 (men) and 28-31 (women)
Wang et al. (2016)13ProspectiveNon-diabetes Type 2 Diabetes315,939 25,458All-cause mortality2-12 yearsLowest mortality at BMI 26.7 (non-diabetes) and 29.1 (type 2 diabetes)
Gu et al. (2006)18ProspectiveAsians154,736All-cause mortality Cause specific mortality8.3 yearsU-shaped association of BMI with all-cause mortality23≤BMI<23.9 (HR 1.09; 95% CI, 1.01-1.19), Reference BMI: 24.0-24.925≤BMI<26.9 (HR 1.00; 95% CI, 0.92-1.08), 27.0≤BMI<29.9 (HR 1.15; 95% CI, 1.06-1.24)Cause specific mortality (CVD, cancer and others): similar U-shaped pattern
Yi et al. (2015)20ProspectiveAsians12,832,637All-cause mortality9-12 yearsAge specific optimal BMI: 23.0-25.9 at 18-34 years (men)24.0-27.9 at 45-54 years25.0-28.9 at 65-74 years15.5-24.9 at 18-34 years (women)21.0-16.9 at 45-54 years24.0-28.9 at 65-74 years
Jee et al. (2006)21ProspectiveAsians1,213,829All-cause mortality Cause-specific mortality12 yearsAll-cause mortality: lowest at BMI 23.0-24.9Risk of death from respiratory causes: higher at a lower BMIRisk of death from CVD and cancer: higher at a higher BMI
Kim et al. (2015)22ProspectiveAsians153,484All-cause mortality CVD mortality Cancer mortality7.91 yearsLowest risk of all-cause mortality: BMI 24-26.4 (HR 0.86; 95% CI, 0.77-0.97, reference BMI: 23-24.9)Lowest risk of the elderly and those with chronic diseases: BMI 25-29.9
J Obes Metab Syndr 2017;26:3~9 https://doi.org/10.7570/jomes.2017.26.1.3