pISSN 2508-6235 eISSN 2508-7576

Table. 4.

Predictive parameters of body weight reduction for responders and non-responders after dapagliflozin treatment

Variable  Responder (N=23)  Non-responder (N=34) P
Age (yr) 59.2±9.4 57.8±10.0 0.684
DM duration (yr) 11.0±5.4 12.3±5.6 0.357
BMI (kg/m2) 27.4±18.3 27.0±3.0 0.922
C-peptide (ng/mL) 3.25±1.07 2.62±1.02 0.023*
Insulin (μIU/mL) 13.6±5.9 11.4±7.5 0.064
HOMA-IR 5.4±2.3 5.4±5.8 0.074
HOMA-β 60.1±48.8 49.4±40.0 0.283

Values are presented as mean±standard deviation.

P<0.05.

Responder is defined patients who achieved ≥5% body weight reduction. Non-responder is classified those who achieved <5% body weight reduction.

HOMA-IR, [FPI (μIU/ml)×FPG (mmol/L)]/22.5; HOMA-β, [20×FPI (μIU/ml)]/[FPG (mmol/L)-3.5.

Yr, year; DM, diabetes mellitus; BMI, body mass index; HOMA-IR, homeostatic model assessment-insulin resistant; HOMA-β, homeostatic model assessment-beta cell function; FPI, fasting plasma insulin; FPG, fasting plasma glucose.

J Obes Metab Syndr 2017;26:107~113 https://doi.org/10.7570/jomes.2017.26.2.107
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