Fig. 1. The cross-talk between retinoid X receptor (RXR), vitamin D receptor (VDR), and peroxisome proliferator-activated receptor (PPAR). VDR and PPAR share a common binding partner RXR and a common binding site in the DNA, steroid and nuclear hormone receptor binding site. Hence the dominance of expression will be dependent on the availability ratio of VDR and PPAR; both have to compete with one another to get engaged with RXR so that they could get inside the nucleus and could bind at their site of interest. If PPAR concentration is higher than the gene expression of its governance will be dominating the cell, if VDR is higher than the genome will be more accessible for it rather than for PPARs. LVH, left ventricular hypertrophy; CVD, cardiovascular disease.
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