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Fig. 2. Chronic high-fat high-sucrose (HFHS) diet induced body weight, body composition, and tissue mass, and muscle function changes. HFHS diet-fed mice had significantly higher body weight (A), average energy intake (B, C), with more fat mass, lean mass, free body fluid (D), while a decreased lean mass per body weight (E), and more wet weight of liver, inguinal white adipose tissue (iWAT), and interscapular brown adipose tissue (iBAT) (F). After 20-week diet regime, hanging time was increased in control diet-fed mice (G), and the grip force of mice decreased in both two diet-fed groups (H) compared to baseline. At 20 weeks, 20-week HFHS feeding regime induced significant reduction in hanging time, grip strength, and both exercise exhaustion time and exhaustion distance (G–I). Values are presented as mean±standard deviation (A–C, G, H: n=12; D–F, I: n=6). *P<0.05, P< 0.01 vs. CON groups (A–C) or CON groups at 0 week (G, H) or CON (D–F); P<0.01 vs. CON groups at 20 weeks; §P<0.05 vs. CON+EX (I). The t-test was used. CON, low-fat diet+plain water feeding group; HFHS; HFHS diet-fed sedentary group; CON+EX, CON exercise group; HFHS+EX, HFHS diet-fed exercise group; SOL, soleus; GAS, gastrocnemius; TA, tibialis anterior; QUAD, quadriceps; eWAT, epididymal white adipose tissue.
J Obes Metab Syndr 2019;28:175~185 https://doi.org/10.7570/jomes.2019.28.3.175