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Fig. 5. Schematic illustrating of the mechanisms for a single bout of exercise in soleus of high-fat high-sucrose (HFHS) induced obese mice. HFHS feeding did not induce the change of phosphorylated AMP-activated protein kinase (pAMPK)/total AMPK (tAMPK) ratio, while increased both LC3II/LC3I ratio as well as P62 expression. Under a single bout of exercise, both LC3II/LC3I ratio and P62 expression decreased, while not facilitating LC3II generation in HFHS diet-fed exercise group mice. All the changes above implied that long-term unhealthy diet promoted the formation of autophagosomes, but blocked their combination with lysosome, and a single bout of exercise accelerates the autophagosome degradation.
J Obes Metab Syndr 2019;28:175~185 https://doi.org/10.7570/jomes.2019.28.3.175