pISSN 2508-6235 eISSN 2508-7576

Download original image
Fig. 1. Potential mechanisms linking obesity to the vulnerability and severity of coronavirus disease 2019 (COVID-19). *Possibly related to the closing of public and private facilities such as community health centers, gyms, swimming pools, parks, and schools on the basis of quarantine strategies during the COVID-19 pandemic; †Possibly related to the quarantine policies and financial effects during the COVID-19 pandemic. Socioeconomic factors: ↓physical activity,40 ↓opportunities for exercise,41 ↑unhealthy food consumption.11 Systemic factors: ↑inflammatory cytokine production,42-44 compromised immune system,45 ↑insulin resistance,46 impaired glucose regulation,46 ↓cardiac function,47 ↓tissue perfusion,48 activation of renin–angiotensin system.49,50 Biomechanical factors: ↓lung compliance,51 ↓functional residual capacity,51 ↑airway hyperresponsiveness, 52 ↑small airway collapse,52 ↑esophageal and gastric pressure,53 ↑obstructive sleep apnea,54 ↑hypoxemia.54 CVD, cardiovascular disease; HT, hypertension; NAFLD, nonalcoholic fatty liver disease; DM, diabetes mellitus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
J Obes Metab Syndr 2020;29:84~98 https://doi.org/10.7570/jomes20056