Fig. 4. Water extract of Artemisia annua (WEAA) reduces body weight gain in Zucker fatty (ZF) rats. Zucker lean (ZL) and ZF rats were orally administered WEAA (50 mg/kg) or water once a day for 11 weeks. (A) Body weight, measured weekly. (B) Body fat mass, as measured using dual energy X-ray absorptiometry after inhalation anesthesia with isoflurane. (C) Relative interscapular brown fat, calculated as the percent of organ weight/body weight. (D) Fat in tissue, calculated by the fat mass divided by the subtraction of the bone mineral content from the total body mass. The experimental groups are as follows: ZL+water, ZF+water, and ZF+WEAA (50 mg/kg). Values are presented as mean± standard deviation (n= 5). All statistical analyses are calculated compared to the ZF+water group. (A, B) Two-way analysis of variance (ANOVA) followed by the Bonferroni post-test was used; (C, D) one-way ANOVA followed by the Dunnett post-test was used. *P < 0.05; †P < 0.01; ‡P < 0.001.
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