Fig. 1. Gene expression landscape of subcutaneous adipose tissues (SATs) after bariatric surgery. (A) Summary of pooled data processing workflow yielding 5,000 genes in 126 post-operative (PostOP) and 111 preoperative (PreOP) SATs. (B) Global expression represented by the first two standard-normalized principal components (PC). Dashed line is the negative identity line linearly separating SATs into regions A (above) and B (below) tested against PreOP/PostOP status by Fisher’s exact test. (C) Welch’s t-test comparison of normalized PCs in PostOP to PreOP. (D) Heat map of 1,188 most variable genes. High (H) and low (L) expression clusters were determined by the unsupervised hierarchical method and associated with PreOP/PostOP status by Fisher’s exact test. (E) Volcano plot showing 44 over- and 395 under-expressed genes identified by the robust linear mixed effect model. OR, odds ratio; NA, not applicable.
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