Journal of Obesity & Metabolic Syndrome



J Korean Soc Study Obes 2003; 12(1): 15-23

Published online March 1, 2003

Copyright © Korean Society for the Study of Obesity.

The Most Associated Risk Factor of the Metabolic Syndrome with C-reactive Protein

Jung-Cheon Son,Bom-Taeck Kim,Duck-Joo1 Lee,Hyun-Kook Choi,Hyun-Joo Chung,Gwang-Min Kim

Department of Family Practice and Community Health, Ajou University College of Medicine, Department of Family Medicine, Sungkyunkwan University School of Medicine1


Background: C-reactive protein has been known as an independent risk factor and prognostic factor for cardiovascular diseases. Metabolic syndrome is a sum of coronary risk factors such as abdominal obesity, elevated blood pressure, hypertension, glucose intolerance and abnormalities in lipid level. The previous studies showed limited relationships between CRP and the risk factors in metabolic syndrome. We investigated the relationships between CRP and the risk factors in metabolic syndrome in adult men and women over 18 years old.
Methods: This study included 2772 people. 577 people of them found to have inflammatory disease excluded. The anthropometry and blood pressure were measured. High sensitive CRP, Lipid profiles, WBC, and ESR were assessed.
Results: CRP in Men (0.10 (±0.004) mg/dL) was significantly higher than that in women (0.08 (±0.003) mg/dL)(P<0.001). In both genders, CRP was significantly higher in people who have metabolic syndrome than in people who don’t. As the number of risk factors increased, CRP was significantly increased (P for trend < 0.001). Waist circumference showed the greatest correlation with CRP in men and women (men; R²=0.132, women; R²=0.166)
Conclusion: CRP was correlated with risk factors in metabolic syndrome in men and women over 18 years old. Of the risk factors waist circumference was most correlated with CRP.

Keywords: C-reactive protein, Metabolic syndrome, Waist circumference