Journal of Obesity & Metabolic Syndrome



J Korean Soc Study Obes 2000; 9(4): 219-228

Published online December 31, 2000

Copyright © Korean Society for the Study of Obesity.

Role of CD38 in Insulin Secretion by Glucose in Pancreatic Beta Cells

Byung-Ju Park,Keum Hee Choi,Tai-Hee Lee1

Department of Biochemistry and Research Institute of Dental Science, Chonnam National University, College of Dentistry, Department of Internal Medicine1, Chonnam National University, Medical School, Kwangju, Korea


CD38 is a transmembrane glycoprotein, which catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a calcium-mobilizing agent that acts independently of inositol trisphosphate. Pancreatic islets were obtained from pancreas of male Balb/c mice weighing 15∼20 g by a collagenase technique. NAD-pretreated isolated islets showed decreased insulin secretion triggered by glucose and inactivated hydrolytic activity of NAD glycohydrolase of CD38 due to ADP-ribosylation. Our results suggest that CD38 has a pivotal role in signal transmission between glucose stimulus and Ca2+-induced insulin secretion.

Keywords: CD38, NAD, Insulin secretion, ADP-ribosylation