Korean J Obes 2005; 14(3): 141-148
Published online July 1, 2005
Copyright © Korean Society for the Study of Obesity.
Yeon Kyeong Kim, Sang Mi Ahn, Young Eun Jo, Yong-Jun Choi, Kyoung Eun Song, Sun Hye Jung, Hae Jin Kim, Yoon-Sok Chung, Kwan Woo Lee, Dae Jung Kim
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea
Resistin is a novel adipocyte-derived hormone that has been proposed to link obesity with insulin resistance and diabetes in mice models. However, many studies in humans have failed to reveal link between circulating resistin levels and adiposity or insulin resistance. Therefore, we conducted a cross-sectional study to evaluate whether resistin correlates with obesity and insulin resistance in children and adolescents. Fifty overweight and 88 normal children, aged 7~17 yr (mean 11.7 ± 1.9 yr) were enrolled. Body composition measurements were performed by dual-energy x-ray absorptiometry scan, and CT scan at the umbilical level was performed to evaluate the distribution of abdominal fat. Serum glucose, insulin and adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor(TNF)-a, interleukin(IL)-6 were measured. Serum resistin levels were significantly higher in overweight than control group (6.02 ± 2.83 vs 5.0 ± 2.7 ng/mL, P < 0.05). Serum resistin levels were positively associated with waist to hip ratio (r = 0.228), body mass index (r = 0.255), total fat mass (r = 0.232), trunk fat percent (r = 0.224), abdominal subcutaneous area (r = 0.246), visceral fat area (r = 0.202), serum leptin (r = 0.251) and TNF-a (r = 0.270) (P < 0.05, respectively).
No associations of serum resistin with serum fasting glucose, insulin levels and HOMA-IR were detected. Using multivariate linear regression models, body weight, adiponectin, sex, visceral fat area, and triglycerides were independently associated with HOMA-IR. Waist circumference and TNF-a were independently associated with resistin levels. Serum resistin levels are associated with obesity but not with insulin resistance. Resistin is unlikely to be a major link between obesity and insulin resistance in children and adolescents.
Keywords: Resistin, Obesity, Insulin resistance, Children, Adolescents