Korean J Obes 2009; 18(4): 131-137
Published online December 1, 2009
Copyright © Korean Society for the Study of Obesity.
Keun Yung Ahn(1), Youn Seon Choi, Dong Won Lee, Kun Young Kim, Jung Hyean Kim, Han Na Sung(1), Kyeung mook Choi(2), Sun Mi Kim, Chang Beom Lee(3)*
Department of Family Medicine, Korea University Medical Center Guro Hospital; Department of Family Medicine, Korea University Medical Center Ansan Hospital(1); Division of Endocrinology & Metabolism, Korea University Medical Center Guro Hospital(2); and Department of Endocrinology and Metabolism, Guri Hospital, Hanyang University School of Medicine(3)
Background: Low grade inflammation has been proposed
as a pathophysiologic mechanism of obesity. Thus, we
sought to determine the relation of C-reactive protein to
obesity in Korean children.
Methods: We selected 585 children aged 9 years in
Seoul. Anthropometric measurements and fasting blood
samples were collected and body mass index (BMI) was
calculated as weight/height2. We measured high-sensitivity
CRP (hs-CRP), glucose (FBS), total cholesterol (TC), high
density lipoprotein cholesterol (HDL-C), and triglyceride
Results: Hs-CRP concentration was positively correlated
with weight, BMI, waist circumference and negatively
correlated with HDL-C. On multivariate analysis, these
variables emerged as independent determinants of hs-CRP
Conclusion: Obesity is associated with higher hs-CRP
concentration. These findings suggest a state of subclinical
inflammation in obese children.
Keywords: obesity, child, C-reactive protein