Journal of Obesity & Metabolic Syndrome

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Korean J Obes 2009; 18(4): 158-166

Published online December 1, 2009

Copyright © Korean Society for the Study of Obesity.

Relationship Between C-reactive Protein, Several Adipokines and Metabolic Risk
Factors in Korean Children

Hea Jin Lee, Kyung Eun Yun, Hye Soon Park*, Seon Mee Kim(1), Kyung Mook Choi(2)

Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine; and Department of Family Medicine(1), Devision of Endocrinology and Metabolism, Department of Internal Medicine(2), Korea University College of Medicine

Abstract

Background: C-reactive protein and adipokines are
associated with obesity and insulin resistance. The
relations between C-reactive protein, adipokines and
metabolic risk factors have been extensively studied in
adults, but there are no comparable data in pre-pubertal
children. We investigated the associations between
C-reactive protein, several adipokines and metabolic risk
factors in pre-pubertal Korean children.
Methods: A total of 324 pre-pubertal children (149
boys and 175 girls) aged 8~9 years were evaluated for
height, weight, blood pressure and body mass index
(BMI). The serum hs-CRP, adiponectin, TNF-α, vaspin,
RBP4, fasting glucose, insulin, lipid profile were also
measured. Overweight was defined as being at or above
the 85th percentile of the gender-specific BMI for age in
the 2007 Korean National Growth Chart.
Results: In boys, serum hs-CRP levels were correlated
with BMI (r = 0.339, P < 0.001), waist circumference
(r=0.356, P<0.001), systolic blood pressure (r = 0.183, P
< 0.05), diastolic blood pressure (r = 0.168, P < 0.05),
ALT (r = 0.311, P < 0.001), insulin (r = 0.226, P < 0.05)
and HOMA-IR (r = 0.199, P < 0.05). In girls, serum
hs-CRP levels were correlated with BMI (r = 0.332, P <
0.001), waist circumference (r = 0.311, P < 0.001),
Triglycerides (r = 0.177, P < 0.05), HDL-C (r = -0.232,
P < 0.001), ALT (r = 0.152, P < 0.05), insulin (r =
0.238, P < 0.01), HOMA-IR (r = 0.233, P < 0.01). Serum
adiponectin levels were negatively correlated with ALT
and AST in boys and total cholesterol levels in girls,
respectively. There was no correlation between serum
TNF-α, vaspin, RBP4 levels and metabolic risk factors in
boys. In girls, serum fasting glucose levels was negatively
correlated with serum TNF-α levels, and positively
correlated with serum vaspin levels. In multiple linear
regression analysis, body mass index was best predictor of
hs-CRP in boys and girls.
Conclusion: Serum hs-CRP was significantly associated
with BMI, waist circumference and other metabolic risk
factors in pre-pubertal children. Among these metabolic
risk factors, BMI was the best predictor of hs-CRP
concentration in both boys and girls. A larger study might
be helpful to characterize the relationship between
metabolic risk factors and inflammatory markers in this
age group.

Keywords: C-reactive protein, adipokine, children, metabolic risk factors