Polycystic ovary syndrome (PCOS) is diagnosed by a
combination of oligo-anovulation, clinical/biochemical signs
of hyperandrogenism, or ultrasound findings consistent with
PCOS. It is also associated with metabolic abnormalities,
such as dyslipidemia, obesity, and glucose intolerance. In
spite of increasing awareness of PCOS in obese
adolescents, its clinical diagnosis is often difficult. We report two cases of PCOS presenting with metabolic
syndrome and hirsutism. They showed dyslipidemia,
insulin resistance and central obesity with waist
circumference above 90 percentile and BMI over 95
percentile for their age and sex matched reference value.
One patient was diagnosed as having type 2 diabetes.
After metformin treatment, there was a significant
reduction in body weight and waist circumference but
hirsutism was not improved. Careful, long-term
observation of these adolescents is needed to evaluate
therapeutic outcomes.

Keywords: Polycystic ovary syndrome, Metabolic
syndrome, Hirsutism, Obesity, Adolescence