Journal of Obesity & Metabolic Syndrome



Korean J Obes 2011; 20(1): 31-35

Published online March 1, 2011

Copyright © Korean Society for the Study of Obesity.

The Association between Serum Monocyte Chemoattractant Protein-1 Levels and Metabolic Syndrome in Korean Adults

Eun-Suk Choi, Won-Young Lee*, Ji-hoon Choi, Won-Jun Kim, Ji-Chul Bae, Seung-Hyun Yoo, Se-Eun Park,Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim

Department of Endocrinology and metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

Background: Recent data have suggested that adipoctye derived monocyte chemoattractant protein-1 (MCP-1) is related to obesity, insulin resistance and atherosclerosis.
This study evaluates the relationship between serum MCP-1 concentrations and components of metabolic syndrome in Korean population.
Methods: Four hundred and ninety five subjects who had participated in the health check-up were enrolled. The presence of metabolic syndrome was assessed according to American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) criteria.
Results: Mean age of the total subjects was 40.8±6.3 years old and 325 (65.3%) male subjects were included.
In bivariate analyses, serum MCP-1 concentrations were positively correlated with body weight, BMI, fasting insulin and serum triglyceride levels whereas it was negatively correlated with HDL-cholesterol levels. Eighty six subjects had metabolic syndrome and were shown to have higher MCP-1 concentrations compared to the subjects without metabolic syndrome. MCP-1 concentrations increased as the number of components of metabolic syndrome increased.
Conclusion: MCP-1 concentrations correlated with the presence and the severity of metabolic syndrome .This result suggests again that inflammation is closely associated with metabolic syndrome in Korean population.
Prospective study is needed to elucidate the temporal association.

Keywords: Monocyte chemoattractant protein-1
(MCP-1), Adipokine, Metabolic syndrome

Baseline characteristics of 495 subjects

Bivariate correlation between serum MCP-1 levels and metabolic parameters

Number of the subjects with each components of metabolic syndrome defined by AHA/NHLBI criteria

Comparisons of the mean serum MCP-1 levels (logarithmically transformed) in subjects with a different number of components of the metabolic syndrome

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