Associations of Serum Vascular Endothelial Growth Factor and Abdominal Fat Distributions in Obese Korean Women

Kyung Eun Yun; Hye Soon Park; Chan Keum Park; Young Sook Song; Yeon Jin Jang

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Korean J Obes 2011; 20(2): 84-90

Published online June 1, 2011

Associations of Serum Vascular Endothelial Growth Factor and Abdominal Fat Distributions in Obese Korean Women

Kyung Eun Yun^*, Hye Soon Park⁽¹⁾, Chan Keum Park⁽²⁾, Young Sook Song⁽²⁾, Yeon Jin Jang⁽²⁾

Health Screening Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine; Department of Family Medicine, University of Ulsan College of Medicine⁽¹⁾, Department of Physiology, University of Ulsan College of Medicine⁽²⁾

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Background: Vascular endothelial growth factor (VEGF) is a very potent angiogenic factor expressed and secreted from adipocytes, and VEGF-mediated angiogenesis is necessary for the adipose tissue expansion associated with human obesity. This study investigates the associations of serum VEGF concentration and abdominal fat distributions in obese Korean women.
Methods: A cross-sectional study was conducted in 37 obese women (BMI ≥ 30 kg/m²) who visited the obesity clinic in a tertiary health care center (Seoul, Korea). Anthropometric indices were measured and abdominal fat distribution was assessed by computed tomography. Fasting plasma glucose, insulin, lipid profiles, and serum VEGF concentrations were measured.
Results: Serum VEGF concentration significantly correlated with BMI (r = 0.478, P = 0.024) and visceral fat area (r = 0.449, P = 0.036) after adjustment for age. In multivariate linear regression analysis, visceral fat area was independently associated with serum VEGF concentration in the study subjects.
Conclusion: The present study shows that visceral fat accumulation is independently associated with elevation of serum VEGF concentrations in obese Korean women. This suggests the intriguing possibility that anti-angiogenic components may reduce visceral fat in obese subjects.

Keywords: VEGF, BMI, Visceral fat accumulation, Obesity

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Basic characteristics of the study participants

Correlations between serum VEGF concentration, anthropometric measirements, and cardiometabolic risk factors in the study participants

Multiple regression analysis for the relationship between serum VEGF concentration with anthropometric measurements and cardiometabolic risk factors

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