Journal of Obesity & Metabolic Syndrome



Korean J Obes 2012; 21(1): 57-64

Published online March 30, 2012

Copyright © Korean Society for the Study of Obesity.

The Effect of Visceral Fat Area and Adipocytokines on Acute Myocardial Infarction: A Case-Control Study in Adult Korean Population

Kang-Kon Lee, Young-Sung Suh(1), Keun-Sang Yum*

Department of Family Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Department of Family Medicine, Keimyung University Dongsan Medical Center(1)

Background: This study aimed to analyze visceral fat area (VFA) and the pattern of secretion of adiponectin, leptin, TNF-α, IL-6, and IL-10. It also studies the effect of VFA and adipocytokines on the risk of Acute myocardial infarction (AMI) in adult Korean population.
Methods: A patient group (PG) consisting of 121 patients, who were hospitalized for AMI from 2008 to 2009, and a control group (CG) consisting of 115 healthy adults, who visited the same hospital for health examination within the same period, were included in this study. Physical measurements were performed and VFA was measured using computed tomography. Lipid, metabolic index,
adipocytokine levels were also measured after 12 hours of fasting.
Results: BMI, waist circumference, levels of leptin, TNF-α, and IL-6 were significantly higher in the PG, while adiponectin level was significantly higher in the CG.
According to the comparison study analyzed by gender, VFA level was significantly higher in the PG, and IL-10 level was significantly higher in the CG. After adjusting for the conventional risk factors (CRF) of AMI, regression analysis showed that adiponectin and IL-10 levels reduced the risk of AMI; whereas VFA, TNF-α, leptin, and IL-6 increased the same risk.
Conclusion: It is postulated that adipocytokines and VFA will act as independent risk factors of AMI regardless of CRF of coronary artery disease.

Keywords: Myocardial infarction, Visceral fat, Adipocytokines

Clinical characteristics of study subjects

Distribution of fat measures and adipocytokines for women and men

Logistic regression analyses for baseline adipocytokines and risk of myocardial infraction

Independent predictors of MI; stepwise logistic regression analyses including traditional cardiovascular risk factors and VFA, adipocytokines

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