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Korean J Obes 2014; 23(3): 203-210

Published online September 30, 2014

Copyright © Korean Society for the Study of Obesity.

The Effects of Marathon Running on Retinol Binding Protein 4 and C-reactive Protein Levels in Healthy Middle-aged Korean Men

Jisuk Chae, Sungmin Kim, Junga Lee*, Justin Y. Jeon

Department of Sport and Leisure Studies, Yonsei University, Seoul, Korea

Received: October 29, 2013; Reviewed : November 12, 2013; Accepted: January 16, 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background: The purpose of this study was to investigate the effects of marathon running (42.195 km) on retinol binding protein4 (RBP4) and C-reactive protein (CRP) in healthy middle aged Korean men.
Methods: Fourteen men aged from 40 to 50 participated in the current study. Eight participants completed marathon running while six participants in the control group took a rest. Blood samples were collected 90 minutes before running the marathon and right after it. Blood samples from the control group were drawn approximately at the same time.
Results: Marathon running (average marathon finishing time: 256.75±11.52 min) did not influence plasma levels of RBP4 (pre: 86.63±28.87 vs. post: 92.22±42.20 μg/mL) or CRP (pre: 0.04±0.04 vs. post: 0.04±0.04 mg/dL). After running the marathon, white blood cells increased by 235% (pre: 5.80±1.64 th/mm3 vs. post: 13.62±3.62 th/mm3). Total cholesterol level also increased significantly after marathon running (P<0.05).
Conclusion: Marathon running did not affect RBP4 or CRP levels, but it increased WBC level significantly. Further studies are needed to elucidate the exact physiological indicators associated with marathon running, as in WBC, RBP4, and CRP.

Keywords: RBP4, Acute aerobic exercise, Marathon, Middle-aged Korean men


Baseline characteristics



Clinical and laboratory parameters of subjects before and after (Hct correction) the marathon running


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