Journal of Obesity & Metabolic Syndrome

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J Obes Metab Syndr 2019; 28(2): 141-142

Published online June 30, 2019 https://doi.org/10.7570/jomes.2019.28.2.141

Copyright © Korean Society for the Study of Obesity.

Response: Association of Z-Score of the Log-Transformed A Body Shape Index with Cardiovascular Disease in People Who Are Obese but Metabolically Healthy: The Korea National Health and Nutrition Examination Survey 2007?2010 (J Obes Metab Syndr 2018;27:158-65)

Wankyo Chung1, Jung Hwan Park2, Ohk-Hyun Ryu3, Jae Myung Yu3, Hyung Joon Yoo3,4, Shinje Moon3,*

1Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Korea; 2Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea; 3Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea; 4Department of Internal Medicine, CM Hospital, Seoul, Korea

Correspondence to:
Shinje Moon,
https://orcid.org/0000-0003-3298-3630,
Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, 1 Singil-ro, Yeongdeungpo-gu, Seoul 07441, Korea,
Tel: +82-2-846-5326,
Fax: +82-2-846-4669,
E-mail: sinjei82@hanmail.net

Received: May 7, 2019; Reviewed : May 23, 2019; Accepted: May 30, 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Clinical outcomes of metabolically healthy obesity (MHO) remain controversial in the previous studies using body mass index (BMI) for defining obesity.1 This might be due to the limitations of BMI, such as an inability to discriminate between muscle and fat or to identify fat location.2 Recent studies reported that A Body Shape Index (ABSI) has an inverse relationship with fat-free mass and can be used for screening sarcopenic obesity.3,4 Therefore, ABSI can be a useful screening tool for identifying high risk individuals with poor clinical outcomes in the MHO group. In this study, we used Z-score of the log-transformed A Body Shape Index (LBSIZ) and found a positive association with the risk of cardiovascular disease (CVD; 1st vs. 3rd tertile: odds ratio, 1.478; 95% confidence interval, 1.192–1.831). In the MHO group, only the subjects in the highest tertile of LBSIZ showed a significantly higher risk of CVD compared to the reference group with metabolically healthy and no obesity with the first tertile of LBSIZ. In addition, LBSIZ had a linear relationship with CVD risks in all obesity phenotypes.

LBSIZ is a measure of abdominal obesity based on waist circumference for a given weight and height. It is a modified version of ABSI that can be used regardless of sex and ethnicity. Furthermore, considering its normal distribution of values, LBSIZ can improve clinical usefulness in actual practice by providing appropriate cutoff values to identify individuals with high risk of CVD. LBSIZ has a limitation in the complicated calculation process, but we provided a template for calculating with waist circumference, weight and height, derived from a representative sample of the Korea National Health and Nutrition Examination Survey.5 Additional template for other races and ethnicities in the United States will be available soon.

In order to establish the superiority and clinical usefulness of LBSIZ, further prospective studies are needed for other ethnic groups. Further studies of the association between LBSIZ and body composition will also be required to understand the underlying pathophysiological rationale of LBSIZ and to assess CVD risk with LBSIZ.

The authors declare no conflict of interest.

  1. Chung W, Park JH, Ryu OH, Yu JM, Yoo HJ, Moon S. Association of Z-score of the log-transformed A Body Shape Index with cardiovascular disease in people who are obese but metabolically healthy: the Korea National Health and Nutrition Examination Survey 2007–2010. J Obes Metab Syndr 2018;27:158-65.
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  3. Biolo G, Di Girolamo FG, Breglia A, Chiuc M, Baglio V, Vinci P, et al. Inverse relationship between “a body shape index” (ABSI) and fat-free mass in women and men: insights into mechanisms of sarcopenic obesity. Clin Nutr 2015;34:323-7.
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  4. Dhana K, Koolhaas CM, Schoufour JD, Rivadeneira F, Hofman A, Kavousi M, et al. Association of anthropometric measures with fat and fat-free mass in the elderly: The Rotterdam study. Maturitas 2016;88:96-100.
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  5. Moon S, Park JH, Ryu OH, Chung W. Effectiveness of Z-score of log-transformed A Body Shape Index (LBSIZ) in predicting cardiovascular disease in Korea: the Korean Genome and Epidemiology Study. Sci Rep 2018;8:12094.
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