Korean J Obes 2011; 20(3): 129-137
Published online September 1, 2011
Copyright © Korean Society for the Study of Obesity.
Hyun Kyung Kim(1), Seung Mo Kang(1), Seung Yup Lee(1), Se Hwan Park(1), Kyung Wan Min(1).(2), Kyung Ah Han(1).(2)*
Department of Internal Medicine, Eulji University School of Medicine(1), Diabetes Clinic, Eulji Medical Center(2)
Background: Type 2 diabetes and obesity are associated with endothelial dysfunction. We sought to determine whether weight reduction or aerobic exercise improves endothelium-dependent vasodilation in overweight type 2 diabetes patients.
Methods: Forty overweight type 2 DM patients (BMI 27.8 ± 2.1 kg/m2, taking metformin or no medication) were enrolled to a 12-week exercise program with or without calorie restricted diet program. The patients were grouped into either control (n = 10) group, exercise group without weight loss (n = 14) or exercise group with calorie-resticted diet (n = 16). We measured body weight, BMI, blood pressure, lipid level, HbA1c and brachial artery flow-mediated dilation (FMD) at baseline and after 12 weeks of exercise and calorie-restricted diet program.
Also, apolipoprotein B, free fatty acid and hsCRP were assessed.
Results: Weight loss was noticed only in the exercise group with calorie-restricted diet (-3.07 ± 1.03 kg). FMD decreased in the exercise group with calorie-restricted diet, but remained unchanged among the control and exercise group without weight loss. Furthermore, ApoB and free fatty acid were improved in exercise group with calorie-restricted diet.
Conclusion: Endothelial dysfunction is improved when weight reduction is accompanied with aerobic exercise in overweight type 2 diabetes patients. Concurrent decrease in ApoB and FFA was also noted with aerobic exercise.
Keywords: Overweight, Weight reduction, Endothelial function, Endothelium dependent dilatation, Aerobic
exercise, Diabetes mellitus