Journal of Obesity & Metabolic Syndrome



J Korean Soc Study Obes 2003; 12(3): 220-227

Published online September 1, 2003

Copyright © Korean Society for the Study of Obesity.

A Study for Weight Changes Associated with Type of Beta3 Adrenergic Receptor Gene after HRT

Ki-ho Lee,Sang-man Kim,Duck-joo Lee,Hee-chung Choi1,In-kwon Han2

Department of Family Practice and Community Health, Department of Internal Medicine2, Samsung Cheil Hospital, School of Medicine, Sungkyunkwan University, Department of Family Medicine, Medical School of Eulji University1


Background: The study results to determine the relationship between postmenopausal estrogen use and weight gain have not been consistent. Genetic studies have reported the association of BMI with the beta3-adrenergic receptor gene polymorhism. This study as designed to indentify association of beta3-adrenergic receptor gene polymorhism with weight gain related to HRT in postmenopausal women.
Methods: 192 postmenopausal women at a general hospital, Bariatric and climacteric clinic have been collected. Subtypes of beta3 adrenergic receptors were measured and physical, anthropomeric data including body fat and BMI was obtained before and after HRT.
Results: Arg/Arg group was 34.8%, Trp/Arg group was 25.0%, Trp/Trp group was 39.1%. Mean weight gain in 192 postmenopausal women was 1.28±3.20 kg and the percent changes in weight gain between initial and final point was 2.32±5.66% but these resulst had no statistical significance (p>0.05). Weight gain(%) were 2.24%(95% C.I 0.35~4.13) in Arg/Arg group, 1.08%(-1.17~3.29) in Trp/Arg group and 3.18%(1.49~4.92) in Trp/Trp, but these results did not show statistical significance(F=1.13, p=0.03).
Conclusion: Polymorphism of beta3 adrenergic receptor gene was not associated with weight gain after HRT in postmenopausal women. From these results, we may conclude that polymorhism of beta3 adrenergic receptor may not be the predicting factor to understand the weight gain after HRT in postmenopausal women.

Keywords: β3-adrenergic receptor, Weight gain, Hormone replacement therapy, Polymorhism, Postmentopausal women