Background : Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and cardiovascular disease. The aim of this study was to investigate the relationships between insulin resistance generated by quantitative insulin sensitivity check index(QUICKI) and regional adiposity, body mass index (BMI), and serum lipid profile in Korean type 2 diabetic patients.
Method: Study subjects included fat mass and lean body mass by dual energy x-ray absorptiometry(DEXA) system. Insulin resistance was estimated by the QUICKI.
Result : 50 were women and 53 were men, with a mean (±SD) age of 54.2 years(±12.8). The mean(±SD) score of QUICKI was 0.38(±0.07). Insulin resistance was positively correlated with total body fat percent, abdominal fat percent, BMI, total cholesterol, LDL-cholesterol, and triglyceride, and negatively correlated with the HDL-cholesterol. In multivariate model, the predicting variables on insulin resistance were abdominal fat percent, HDL cholesterol, and total cholesterol.
Conclusion: In this study, we observed that the abdominal fat percent, HDL cholesterol and total cholesterol were meaningful variables correlated with insulin resistance among variables. Therefore, to improve insulin sensitivity in Korean type 2 diabetic patients, we should reduce the abdominal fat percent and total cholesterol and increase the level of HDL-cholesterol.

Keywords: QUICKI, Insuline resistance, Abdominal fat percent, Type 2 DM