Journal of Obesity & Metabolic Syndrome

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Korean J Obes 2008; 17(2): 65-72

Published online June 1, 2008

Copyright © Korean Society for the Study of Obesity.

Relationship between AHI and insulin resistance, serum adiponectin, and visfatin

Young sung Suh,Byung Hoon Ahn(1),Sang Hee Hwang(2),Young Woo Cho(3)*

Department of Family Medicine,Otolaaryngology(1), Dentistry(2),and Neurology,Keimyung University College of Medicine

Abstract

Background: Obstructive sleep apnea (OSA) is closely
related to insulin resistance. Adipocytokines, adiponectin
and visfatin, may induce the development of insulin
resistance among OSA patients. Therefore, we examined
the relationships between apnea-hypopnea index (AHI)
and insulin resistance; between AHI and adiponectin; and
between AHI and visfatin in Korean snoring subjects.
Methods: Eighty one adult habitual snorers who visited
the hospital for an examination of polysomnography were
divided into either simple snorers (AHI < 5), mild OSA
subjects(AHI 5 ≤ to < 15), or moderate and severe OSA
subjects (AHI ≥ 15). Anthropometric data were measured.
The serum adiponectin, visfatin, and insulin were
measured. Insulin resistance was measured as homeostasis
model assessment (HOMA-IR).
Results: After adjusting for age, sex and waist
circumference (WC), insulin, HOMA-IR, and adipocytokines
were not different among the subgroups. Fasting insulin
level and HOMA-IR were positively correlated with body
mass index (BMI), WC, hip circumference (HC) and AHI.
In addition, HOMA-IR was positively correlated with age.
The serum adiponectin level was inversely associated with
WC and AHI but positively associated with sex. The
serum level of visfatin was negatively correlated with sex.
Stepwise multiple regression analysis indicated that WC
was an independent variable of fasting insulin (Adj R2 =
0.340) and HOMA-IR (Adj R2 = 0.322) also WC and sex
were independent determinants of adiponectin level (Adj
R2 = 0.161). Sex was shown to be a predictor of visfatin
level (Adj R2 = 0.039).
Conclusion: Waist circumference was found to be
independently associated with insulin resistance among the
snoring subjects. However, AHI did not serve as a
predictor of adiponectin and visfatin.

Keywords: AHI, snoring, adiponectin, HOMA-IR, visfatin