Journal of Obesity & Metabolic Syndrome



Korean J Obes 2009; 18(1): 8-13

Published online March 1, 2009

Copyright © Korean Society for the Study of Obesity.

Relationship between Circulating Obestatin Levels and Obesity Index in Obese Patients

Jun Goo Kang, Chang Beom Lee(1)†, Heesoon Park(2), Cheol Young Park(3)*

Department of Internal Medicine, College of Medicine, Hallym University; Department of Internal Medicine, Hanyang University Medical College(1); and Diabetes Research Center(2) and Department of Internal Medicine(3), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine


Background: Obestain is a recently identified hormone
that is encoded by ghrelin gene. The mean serum
obestatin level, fasting level, and 2 hour after glucose
loading level were measured in normal weight and obese
subjects. Associations of serum obestatin levels with
metabolic parameters were investigated.
Methods: The association between obestatin level with
anthropometric and metabolic parameters were examined
in 13 obese and 12 normal weight subjects.
Results: No sex differences were found in fasting, 2
hour after glucose loading and mean serum obestatin
level. Fasting and mean serum obestatin levels were lower
in the obese group compared to the normal weight
controls. However, no apparent changes were observed in
2 hour after glucose loading obestatin levels. Fasting
serum obestatin levels were negatively correlated with
BMI, waist circumference, fasting insulin levels, fasting
c-peptide levels and HOMA-IR, and positively correlated
with total cholesterol levels. However, only BMI was an
independent predictor of fasting serum obestatin levels
after adjusting for age, sex and correlated factors
Conclusion: Circulating obestatin is increased in
normal weight and decreased in obese subjects. Our
results suggest that obestatin may play a potential role in
body weight regulation.

Keywords: Obesity, Obestatin, Insulin resistance