Korean J Obes 2009; 18(1): 15-22
Published online March 1, 2009
Copyright © Korean Society for the Study of Obesity.
Jung Hwan Kim, Gum Joo Cho(1), Kyung Mook Choi(2), Jee Hye Han, Dokyung Yoon(3), Seon Mee Kim(3)*
Department of Family Medicine, Eulji Hospital, Eulji University School of Medicine; Guro-Gu Public Health Centre(1); and Division of Endocrinology and Metabolism, Department of Internal Medicine(2), Department of Family Medicine(3), Korea University College of Medicine
Background: Visfatin is known to be secreted from
visceral adipose tissue and have insulin-mimetic effect.
Therefore, visfatin is considered to be related to obesity,
especially central obesity, insulin resistance and metabolic
syndrome. However, results confirming these theories are
not available. This study was conducted to investigate the
relationship between obesity, metabolic syndrome and
serum visfatin concentration.
Methods: Total of 85 subjects were recruited. They
were females of 30 to 60 years of aged who were not
diagnosed as diabetics. The subjects were divided into
normal weight group and obese group. They were further
divided into with or without metabolic syndrome groups.
The serum visfatin levels of each group were compared.
The correlation between serum visfatin concentration and
biologic profiles were analyzed. Multiple linear regression
analysis was done. All subjects were divided into 4
groups according to serum visfatin levels. Prevalence of
metabolic syndrome and various variables related to
metabolic syndrome of each group were compared.
Results: The serum visfatin in the obese group was
significantly higher than that of the normal weight group
(P = 0.002). There was no significant difference in serum
visfatin between with and without metabolic syndrome
groups (P = 0.340). The serum visfatin had correlation
with weight, body mass index, waist and hip
circumference. There was no significant correlation
between serum visfatin levels and prevalence of metabolic
syndrome. Prevalence of high blood pressure, however,
had a significant correlation with serum visfatin levels.
Conclusion: Obesity, especially central obesity, had a
significant association with serum visfatin concentration
but failed to show any significant correlation with either
metabolic syndrome or insulin resistance.
Keywords: Visfatin, Metabolic syndrome X, Insulin resistance