Journal of Obesity & Metabolic Syndrome

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Korean J Obes 2011; 20(1): 16-22

Published online March 1, 2011

Copyright © Korean Society for the Study of Obesity.

The Association of Homocysteine and Metabolic Syndrome

Kyoung Pil Shin(1), Sang-Yeoup Lee(2).(3), Yun Jin Kim(1).(4), Jeong Gyu Lee(1).(4)*, Dong-Hee Kim(5), Dong-Wook Jung(2), Yu-Hyeon Yi(4), Seon Ki Park(2), Young-Hye Cho(2)

Department of Family Medicine, Pusan National University School of Medicine(1), Family Medicine Clinic, Pusan National University Yangsan Hospital(2), Medical Education Unit, Pusan National University School of Medicine(3), Department of Family Medicine, Pusan National University Hospital(4), College of Nursing, Pusan National University(5)

Background: Metabolic syndrome is a cluster of all the risk factors of cardiovascular diseases, in which insulin resistance plays a key role as the pathogenesis.
Homocysteine is an amino acid that is generated during methionine metabolism. It is associated with insulin resistance. However, there is a controversy concerning the corelation between homocysteine and metabolic syndrome.
This study is designed to further investigate this subject.
Methods: A total of 4488 patients who were older than 20 years of age and visited the Health Promotion Center of a university affiliated hospital from Jan 1, 2007 to Dec 31, 2007 were assigned to this study. Modified ATP III definition was used for diagnosis of metabolic syndrome while Korean standard for waist circumference was used.
This study tried to prove the correlation of homocysteine concentration and metabolic syndrome by using two statistical tools. The first was the comparison of homocysteine concentration between the group with and without metabolic syndrome. The second was the prevalence ratio of metabolic syndrome according to the level of homocysteine concentration.
Results: The group with metabolic syndrome showed a significantly higher level of homocysteine compared to the other groups (9.10 vs 7.97, P < 0.001). In comparison to the group with the lowest (< 5.90 mg/L, Q1) homocysteine level, the prevalence of metabolic syndrome among the other groups (Q2.Q3 and Q4) were significantly higher with odds ratio being 1.28, 1.48 and 1.41 for groups Q2, Q3, and Q4, respectively.
Conclusion: Metabolic syndrome was shown to have a significant correlation with a high level of homocysteine.
Therefore, lowering homocysteine level may help prevent metabolic syndrome.

Keywords: Homocysteine, Metabolic syndrome, Prevention of metabolic syndrome, Insulin resistance


Demographic and clinical characteristics of study group



Correlation of serum homocysteine level and markers of cardiovascular risk



Prevalence of metabolic syndrome according to quartiles of serum homocysteine (mean ± SD)



Logistic regression analysis for metabolic syndrome


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