Journal of Obesity & Metabolic Syndrome



Korean J Obes 2013; 22(4): 237-242

Published online December 31, 2013

Copyright © Korean Society for the Study of Obesity.

The Relationships Between Blood Mercury Concentration and Body Composition Measures Using 2010 Korean National Health and Nutrition Examination Survey

Dae-won Kang, Ka-young Lee*

Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine

Received: March 18, 2013; Reviewed : April 8, 2013; Accepted: April 18, 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background: We evaluated the relationships between blood mercury level and body composition measures in Korean adults using 2010 Korean National Health and Nutrition Examination Survey (KNHANES).
Methods: The sample from 2010 KNHANES data consisted of 1,853 adults (918 males, 935 females) aged 20 years or older. The relationships between blood mercury concentration and body composition measures (including body mass index (BMI), waist circumference (WC), total fat mass, total lean mass, percentage of total body fat (PBF), truncal fat mass, truncal lean mass, and percentage of truncal fat) were analyzed using multiple linear regression and logistic regression after adjusting for confounders such as sex, age, education level, physical activity, daily energy intake, fish consumption, smoking, and alcohol use.
Results: In multiple linear regression analysis, blood mercury concentration was significantly and positively associated with body composition measures except for PBF after adjusting for confounders. The odds ratios for obesity (BMI ≥ 25 kg/m2) and abdominal obesity (WC ≥ 90 cm for men and 85 cm for women) increased with higher sex-specific quartiles of blood mercury concentration (P for linear trend < 0.05).
Conclusion: High blood mercury level may be an indicator of obesity and abdominal obesity.

Keywords: Mercury, Obesity, Body composition

The distribution of characteristics according to gender specific quartiles of blood mercury concentration

The relationships of blood mercury concentration (per 1 ?g/L increase) with body composition measures

The odds ratios (95% CI) of gender specific quartiles of blood mercury concentration for obesity/abdominal obesity*

The odds ratios (95% CI) of gender specific quartiles of blood mercury concentration for hypertension and dyslipidemia*

  1. Kim CW, Kim YW, Chae CH, Son JS, Park SH, Koh JC, et al. The effects of the frequency of fish consumption on the blood mercury levels in Koreans. Korean J Occup Environ Med 2010;22:114-21.
  2. Houston MC. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, myocardial infarction. Altern Ther Health Med 2007 Suppl;13:128-33.
  3. Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 1995;25:1-24.
    Pubmed CrossRef
  4. de Marco KC, Passos CJ, Sertorio J, Tanus-Santos JE, Barbosa F Jr. Environmental exposure to methylmercury is associated with a decrease in nitric oxide production. Basic Clin Pharmacol Toxicol 2010;106:411-5.
  5. Stern AH. A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment. Environ Res 2005;98:133-42.
    Pubmed CrossRef
  6. Guallar E, Sanz-Gallardo MI, van’t Veer P, Bode P, Aro A, G?mez-Aracena J, et al. Mercury, fish oils, the risk of myocardial infarction. N Engl J Med 2002;347:1747-54.
    Pubmed CrossRef
  7. Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, et al. Mercury and the risk of coronary heart disease in men. N Engl J Med 2002;347:1755-60.
    Pubmed CrossRef
  8. Valera B, Dewailly E, Poirier P. Environmental mercury exposure and blood pressure among Nunavik Inuit adults. Hypertension 2009;54:981-6.
    Pubmed CrossRef
  9. Choi AL, Weihe P, Budtz-Jørgensen E, Jørgensen PJ, Salonen JT, Tuomainen TP, et al. Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men. Environ Health Perspect 2009;117:367-72.
    Pubmed KoreaMed CrossRef
  10. You CH, Kim BG, Kim JM, Yu SD, Kim YM, Kim RB, et al. Relationship between blood mercury concentration and waist-to-hip ratio in elderly Korean individuals living in coastal areas. J Prev Med Public Health 2011;.44:218 -25.
  11. Korea Centers for Disease Control and Prevention. Korea National Health and Nutrition Examination Survey 2010 (KNHANES V). Seoul: Korea Centers for Disease Control and Prevention; 2012.
  12. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007;75:72-80.
    Pubmed CrossRef
  13. Barbosa AC, Jardim W, D?rea JG, Fosberg B, Souza J. Hair mercury speciation as a function of gender, age, body mass index in inhabitants of the Negro River basin, Amazon, Brazil. Arch Environ Contam Toxicol 2001;40:439-44.
    Pubmed CrossRef
  14. Wiggers GA, Pe?anha FM, Briones AM, P?rez-Gir?n JV, Miguel M, Vassallo DV, et al. Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart Circ Physiol 2008;295:H1033-43.
    Pubmed CrossRef
  15. Alissa EM, Ferns GA. Heavy metal poisoning and cardiovascular disease. J Toxicol 2011;2011:870125.
  16. Kawakami T, Hanao N, Nishiyama K, Kadota Y, Inoue M, Sato M, et al. Differential effects of cobalt and mercury on lipid metabolism in the white adipose tissue of high-fat diet-induced obesity mice. Toxicol Appl Pharmacol 2012;258:32-42.
    Pubmed CrossRef
  17. Laks DR. Assessment of chronic mercury exposure within the U.S. population, National Health and Nutrition Examination Survey, 1999-2006. Biometals 2009;22:1103-14.
    Pubmed CrossRef