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Korean J Obes 2014; 23(2): 79-82

Published online June 30, 2014

Copyright © Korean Society for the Study of Obesity.

Peripheral Neuropathy in Metabolic Syndrome

Junghyun Noh

Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Peripheral neuropathy is a chronic disease that causes significant morbidity and affects an individual’s quality of life by causing pain and gait disturbance. Diabetes is the most common cause of peripheral neuropathy. However, in many patients with peripheral neuropathy no cause is discovered. There are many evidence suggesting that the components of metabolic syndrome such as obesity, dyslipidemia, and impaired glucose tolerance are associated with the development of peripheral neuropathy. Insulin resistance, the core pathophysiology of metabolic syndrome, is considered a culprit in development of neuropathy in metabolic syndrome. Insulin resistance may decrease insulin signaling and cause mitochondrial dysfunction in the peripheral nervous system. The markers of peripheral nerve function as well as the component of metabolic syndrome were improved after lifestyle intervention in subjects with impaired glucose tolerance (IGT) and neuropathy. These findings suggest that improving the components of metabolic syndrome may have positive effects on recovery of the peripheral nerve function.

Keywords: Metabolic syndrome, Peripheral neuropathy

  1. Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease:challenges and opportunities. Science 2013;339:166-72.
    Pubmed KoreaMed CrossRef
  2. Sesti G. Pathophysiology of insulin resistance. Best Pract Res Clin Endocrinol Metab 2006;20:665-79.
    Pubmed CrossRef
  3. Gregg EW, Sorlie P, Paulose-Ram R, Gu Q, Eberhardt MS, Wolz M, et al. Prevalence of lower-extremity disease in the US adult population ≥40 years of age with and without diabetes: 1999-2000 national health and nutrition examination survey. Diabetes Care 2004;27:1591-7.
    Pubmed CrossRef
  4. Won JC, Ko KS. The epidemiology of diabetic neuropathy in Korea. Korean Clin Diabetes J 2010;11:177-82.
  5. Singleton JR, Smith AG, Russell JW, Feldman EL. Microvascular complications of impaired glucose tolerance. Diabetes 2003;52:2867-73.
    Pubmed CrossRef
  6. Van Acker K, Bouhassira D, De Bacquer D, Weiss S, Matthys K, Raemen H, et al. Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics. Diabetes Metab 2009;35:206-13.
    Pubmed CrossRef
  7. Straub RH, Elbracht R, Kr?mer BK, Roth M, Palitzsch KD, Sch?lmerich J. Influence of digoxin-like immunoreactive factor on late complications in patients with diabetes mellitus. Eur J Clin Invest 1994;24:482-7.
    Pubmed CrossRef
  8. Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, IonescuTirgoviste C, et al. Vascular risk factors and diabetic neuropathy. N Engl J Med 2005;352:341-50.
    Pubmed CrossRef
  9. Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA 2002;287:2563-9.
    CrossRef
  10. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405-12.
    Pubmed KoreaMed CrossRef
  11. Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet 2010;376:419-30.
    CrossRef
  12. Novella SP, Inzucchi SE, Goldstein JM. The frequency of undiagnosed diabetes and impaired glucose tolerance in patients with idiopathic sensory neuropathy. Muscle Nerve 2001;24:1229-31.
    Pubmed CrossRef
  13. Singleton JR, Smith AG, Bromberg MB. Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy. Diabetes Care 2001;24:1448-53.
    Pubmed CrossRef
  14. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology 2003;60:108-11.
    Pubmed CrossRef
  15. Hughes RA, Umapathi T, Gray IA, Gregson NA, Noori M, Pannala AS, et al. A controlled investigation of the cause of chronic idiopathic axonal polyneuropathy. Brain 2004;127:1723-30.
    Pubmed CrossRef
  16. Smith AG, Rose K, Singleton JR. Idiopathic neuropathy patients are at high risk for metabolic syndrome. J Neurol Sci 2008;273:25-8.
    Pubmed KoreaMed CrossRef
  17. Sugimoto K, Murakawa Y, Sima AA. Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord. J Peripher Nerv Syst 2002;7:44-53.
    Pubmed CrossRef
  18. Xu QG, Li XQ, Kotecha SA, Cheng C, Sun HS, Zochodne DW. Insulin as an in vivo growth factor. Exp Neurol 2004;188:43-51.
    Pubmed CrossRef
  19. Brussee V, Cunningham FA, Zochodne DW. Direct insulin signaling of neurons reverses diabetic neuropathy. Diabetes 2004;53:1824-30.
    Pubmed CrossRef
  20. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, et al. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 2000;105:311-20.
    Pubmed KoreaMed CrossRef
  21. Carlson CJ, Koterski S, Sciotti RJ, Poccard GB, Rondinone CM. Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression. Diabetes 2003;52:634-41.
    Pubmed CrossRef
  22. Kim B, McLean LL, Philip SS, Feldman EL. Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons. Endocrinology 2011;152:3638-47.
    Pubmed KoreaMed CrossRef
  23. Vincent AM, Hayes JM, McLean LL, Vivekanandan-Giri A, Pennathur S, Feldman EL. Dyslipidemia-induced neuropathy in mice:the role of oxLDL/LOX-1. Diabetes 2009;58:2376-85.
    Pubmed KoreaMed CrossRef
  24. Navarro X, Sutherland DE, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 1997;42:727-36.
    Pubmed CrossRef
  25. Smith AG, Russell J, Feldman EL, Goldstein J, Peltier A, Smith S, et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care 2006;29:1294-9.
    Pubmed CrossRef