Journal of Obesity & Metabolic Syndrome

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Korean J Obes 2009; 18(4): 131-137

Published online December 1, 2009

Copyright © Korean Society for the Study of Obesity.

Relationship Between C-reactive Protein and Obesity in Children

Keun Yung Ahn(1), Youn Seon Choi, Dong Won Lee, Kun Young Kim, Jung Hyean Kim, Han Na Sung(1), Kyeung mook Choi(2), Sun Mi Kim, Chang Beom Lee(3)*

Department of Family Medicine, Korea University Medical Center Guro Hospital; Department of Family Medicine, Korea University Medical Center Ansan Hospital(1); Division of Endocrinology & Metabolism, Korea University Medical Center Guro Hospital(2); and Department of Endocrinology and Metabolism, Guri Hospital, Hanyang University School of Medicine(3)

Abstract

Background: Low grade inflammation has been proposed
as a pathophysiologic mechanism of obesity. Thus, we
sought to determine the relation of C-reactive protein to
obesity in Korean children.
Methods: We selected 585 children aged 9 years in
Seoul. Anthropometric measurements and fasting blood
samples were collected and body mass index (BMI) was
calculated as weight/height2. We measured high-sensitivity
CRP (hs-CRP), glucose (FBS), total cholesterol (TC), high
density lipoprotein cholesterol (HDL-C), and triglyceride
(TG).
Results: Hs-CRP concentration was positively correlated
with weight, BMI, waist circumference and negatively
correlated with HDL-C. On multivariate analysis, these
variables emerged as independent determinants of hs-CRP
concentration.
Conclusion: Obesity is associated with higher hs-CRP
concentration. These findings suggest a state of subclinical
inflammation in obese children.

Keywords: obesity, child, C-reactive protein