Relationship Between C-reactive Protein and Obesity in Children

Keun Yung Ahn; Youn Seon Choi; Dong Won Lee; Kun Young Kim; Jung Hyean Kim; Han Na Sung; Kyeung mook Choi; Sun Mi Kim; Chang Beom Lee

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Korean J Obes 2009; 18(4): 131-137

Published online December 1, 2009

Relationship Between C-reactive Protein and Obesity in Children

Keun Yung Ahn⁽¹⁾, Youn Seon Choi, Dong Won Lee, Kun Young Kim, Jung Hyean Kim, Han Na Sung⁽¹⁾, Kyeung mook Choi⁽²⁾, Sun Mi Kim, Chang Beom Lee^(3)*

Department of Family Medicine, Korea University Medical Center Guro Hospital; Department of Family Medicine, Korea University Medical Center Ansan Hospital⁽¹⁾; Division of Endocrinology & Metabolism, Korea University Medical Center Guro Hospital⁽²⁾; and Department of Endocrinology and Metabolism, Guri Hospital, Hanyang University School of Medicine⁽³⁾

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Abstract

Background: Low grade inflammation has been proposed
as a pathophysiologic mechanism of obesity. Thus, we
sought to determine the relation of C-reactive protein to
obesity in Korean children.
Methods: We selected 585 children aged 9 years in
Seoul. Anthropometric measurements and fasting blood
samples were collected and body mass index (BMI) was
calculated as weight/height2. We measured high-sensitivity
CRP (hs-CRP), glucose (FBS), total cholesterol (TC), high
density lipoprotein cholesterol (HDL-C), and triglyceride
(TG).
Results: Hs-CRP concentration was positively correlated
with weight, BMI, waist circumference and negatively
correlated with HDL-C. On multivariate analysis, these
variables emerged as independent determinants of hs-CRP
concentration.
Conclusion: Obesity is associated with higher hs-CRP
concentration. These findings suggest a state of subclinical
inflammation in obese children.