In the present study we determined whether uric acid concentration is associated with free fat acid, cardiovascular risk factors and intraperitoneal fat. We have studied in 203 subject(134 women and 46 men) for Ajou University obesity clinic. We have measured BMI(body mass index), WHR(waist/hip ratio), blood pressure, serum uric acid, serum lipid profile, free fat acid, fasting insulin, inrapeitoneal fat. Serum uric acid concentration showed positive associations with sex(r = 0.43, P < 0.01), WHR(r = 0.18, P < 0.05), cholesterol(r = 0.20, P < 0.05), triglyceride(r= 0.24, P <0.01), free fat acid(r = 0.32, P < 0.01), visceral/subcutaneous fat ratio(r = 0.27, P < 0.01), blood pressure(r = 0.28, 0.26 P < 0.01). While the adjustment for sex, BMI, age markedly decrease these positive correlation. In multivariate linear regression analysis, free fat acid, visceral/subcutaneous fat ratio, BMI were independent positive predictors of uric acid(R2 = 0.330, P < 0.05), while triglyceride, WHR, sex, age did not give any independent contribution to explain the variability cric acid levels. These data indicate that serum uric acid concentration associated with free fat acid, lipid profile(cholesterol, TG, LDL), v/s ratio. But, the results from this study may have limitations in interpretation since only the obese patients were included.

Keywords: Uric acid, Free fat acid, V/S ratio, Cardiovascular risk factor